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Fat Body Cells Are Motile and Actively Migrate to Wounds to Drive Repair and Prevent Infection

Franz, A; Wood, W; Martin, P; (2018) Fat Body Cells Are Motile and Actively Migrate to Wounds to Drive Repair and Prevent Infection. Developmental Cell , 44 (4) 460-470.e3. 10.1016/j.devcel.2018.01.026. Green open access

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Abstract

Adipocytes have many functions in various tissues beyond energy storage, including regulating metabolism, growth, and immunity. However, little is known about their role in wound healing. Here we use live imaging of fat body cells, the equivalent of vertebrate adipocytes in Drosophila, to investigate their potential behaviors and functions following skin wounding. We find that pupal fat body cells are not immotile, as previously presumed, but actively migrate to wounds using an unusual adhesion-independent, actomyosin-driven, peristaltic mode of motility. Once at the wound, fat body cells collaborate with hemocytes, Drosophila macrophages, to clear the wound of cell debris; they also tightly seal the epithelial wound gap and locally release antimicrobial peptides to fight wound infection. Thus, fat body cells are motile cells, enabling them to migrate to wounds to undertake several local functions needed to drive wound repair and prevent infections.

Type: Article
Title: Fat Body Cells Are Motile and Actively Migrate to Wounds to Drive Repair and Prevent Infection
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.devcel.2018.01.026
Publisher version: https://doi.org/10.1016/j.devcel.2018.01.026
Language: English
Additional information: © 2018 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: adipocytes, fat body, Drosophila, cell migration, wound healing, wound infection, antimicrobial peptides (AMPs), hemocytes, inflammatory response
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: https://discovery.ucl.ac.uk/id/eprint/10073339
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