Leuzy, A;
Heurling, K;
Ashton, NJ;
Schöll, M;
Zimmer, ER;
(2018)
In vivo Detection of Alzheimer's Disease.
Yale Journal of Biology and Medicine
, 91
(3)
pp. 291-300.
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Abstract
Recent revisions to the diagnostic criteria for Alzheimer’s disease (AD) incorporated conceptual advances in the field. Specifically, AD is now recognized to encompass a continuum, spanning from preclinical (accruing brain pathology in the absence of symptoms) through symptomatic predementia (prodromal AD, mild cognitive impairment) and dementia phases. The role of biological markers (biomarkers) of both the underlying molecular pathologies and related neurodegenerative changes has also been acknowledged. In this abridged review, we provide an overview of fluid (cerebrospinal fluid and blood) and molecular imaging-based biomarkers used within the field and discuss the potential role of computer driven artificial intelligence approaches for both the early and accurate identification of AD and as a tool for population enrichment in clinical trials testing candidate disease modifying therapies.
| Type: | Article |
|---|---|
| Title: | In vivo Detection of Alzheimer's Disease |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| Publisher version: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC61536... |
| Language: | English |
| Additional information: | This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License, which permits for noncommercial use, distribution, and reproduction in any digital medium, provided the original work is properly cited and is not altered in any way. https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Keywords: | Alzheimer’s disease, Diagnosis, Medical imaging, Fluid biomarkers |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10073318 |
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