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Estimating sodium intake from spot urine samples at population level: a validation and application study in French adults

Emeville, E; Lassale, C; Castetbon, K; Deschamps, V; Salanave, B; Vernay, M; Guergour, D; ... Verdot, C; + view all (2019) Estimating sodium intake from spot urine samples at population level: a validation and application study in French adults. British Journal of Nutrition , 122 (2) pp. 186-194. 10.1017/S0007114519000886. Green open access

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Abstract

The aim of this study was to assess the validity of the predictive INTERSALT equation using spot urine samples to estimate 24-hour urinary sodium (24-hUNa) excretion and daily sodium intake among the French adult population. Among 193 French adults ("validation sample"), we assessed the validity by comparing predicted 24-hUNa excretion from spot urine and measured 24-hUNa excretion from 24-hour urine collections. Spearman correlation coefficients and Bland-Altman plots were used and we calculated calibration coefficients. In a nationally representative sample of 1,720 French adults ("application sample"), the calibrated predictive equation was then applied to the spot urine Na values to estimate 24-hUNa excretion and daily Na intake. In that sample, predicted Na intake was compared to that estimated from 24-hour dietary recalls. Results were adjusted and corrected using calibration coefficients. In the validation sample, the measured 24-hUNa excretion was on average 14% higher than the predicted 24-hUNa (+ 13% for men and + 16% for women). Correlation between measured and predicted 24-hUNa excretion was moderate (Spearman r = 0.42) and the Bland-Altman plots showed underestimation at lower excretion level and overestimation at higher level. In the application study, estimated daily salt intake was 8.0 g/day using dietary recalls, 8.1 g/day using predicted INTERSALT equation and 9.3 g/day after applying calibration coefficients calculated in the validation study. Despite overall underestimation of 24-hUNa excretion by spot urinary sodium, the use of predictive INTERSALT equation remains an acceptable alternative in monitoring global Na intake/excreted in the French population but its use is not advised at the individual level.

Type: Article
Title: Estimating sodium intake from spot urine samples at population level: a validation and application study in French adults
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1017/S0007114519000886
Publisher version: https://doi.org/10.1017/S0007114519000886
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Predictive INTERSALT equation, salt intake, spot urine samples, urinary sodium excretion
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health
URI: https://discovery.ucl.ac.uk/id/eprint/10073296
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