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Stroma in normal and cancer wound healing

Huet, E; Jaroz, C; Nguyen, HQ; Belkacemi, Y; de la Taille, A; Stavrinides, V; Whitaker, H; (2019) Stroma in normal and cancer wound healing. FEBS Journal , 286 (15) 10.1111/febs.14842. Green open access

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Abstract

It is currently believed that stroma, the connective framework of biological tissues, plays a central role in normal wound healing and in cancer. In both these contexts, stromal cellular components such as activated fibroblasts interact with complex protein networks that include growth factors, structural protein or proteinases in order to initiate and sustain an extensive remodelling process. However, although this process is usually spatially and temporally self-limited, it is unregulated in the case of cancer and leads to uncontrolled cell proliferation and invasion within tissues, metastasis and therapeutic resistance. In this review, we outline the role of stroma in normal healing, cancer and post radiotherapy, with a particular focus on the crosstalk between normal or cancer cells and fibroblasts. Understanding these mechanisms is particularly important as several stromal components have been proposed as potential therapeutic targets.

Type: Article
Title: Stroma in normal and cancer wound healing
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/febs.14842
Publisher version: https://doi.org/10.1111/febs.14842
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: EMMPRIN, FAPα, TGFβ, cancer-associated fibroblasts, fibroblasts, fibrosis, myofibroblasts, radiotherapy, tumour microenvironment, wound healing
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Targeted Intervention
URI: https://discovery.ucl.ac.uk/id/eprint/10073268
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