Tang, JYM;
Luo, H;
Wong, GHY;
Lau, MMY;
Joe, GM;
Tse, MA;
Ip, P;
... Lum, TYS; + view all
(2019)
Bone mineral density from early to middle adulthood in persons with Down syndrome.
Journal of Intellectual Disability Research
, 63
(8)
pp. 936-946.
10.1111/jir.12608.
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Abstract
BACKGROUND: While accelerated ageing is recognised among individuals with Down syndrome (DS), the trajectory of their bone health across adulthood remains poorly understood. METHODS: This study aimed to determine the age‐related loss of bone mineral density (BMD) of the lumbar spine in 128 adults with DS aged 18 to 54 years compared with 723 counterparts without DS. RESULTS: Men and women with DS had lower level of BMD than counterparts without DS across age groups. Magnitude of decrement in BMD as reflected in the z‐scores was similar between younger and older men with DS. Older women with DS, on the contrary, showed greater decrement in older ages especially in their fourth decade of life. Osteopenia and osteoporosis as defined using age‐specific and gender‐specific T‐scores affected greater number of men with DS (38% and 25%) than women (17% and 17%) aged 40–49 years. CONCLUSIONS: Findings supported adults with DS, especially men, to have early bone mineral testing.
| Type: | Article |
|---|---|
| Title: | Bone mineral density from early to middle adulthood in persons with Down syndrome |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/jir.12608 |
| Publisher version: | https://doi.org/10.1111/jir.12608 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | bone loss, bone mineral testing, Down syndrome, intellectual disability, osteoporosis |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Practice and Policy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10073191 |
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