Ardain, A;
Porterfield, JZ;
Kloverpris, HN;
Leslie, A;
(2019)
Type 3 ILCs in Lung Disease.
Frontiers in Immunology
, 10
, Article 92. 10.3389/fimmu.2019.00092.
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Abstract
The lungs represent a complex immune setting, balancing external environmental signals with a poised immune response that must protect from infection, mediate tissue repair, and maintain lung function. Innate lymphoid cells (ILCs) play a central role in tissue repair and homeostasis, and mediate protective immunity in a variety of mucosal tissues, including the lung. All three ILC subsets are present in the airways of both mice and humans; and ILC2s shown to have pivotal roles in asthma, airway hyper-responsiveness, and parasitic worm infection. The involvement of ILC3s in respiratory diseases is less well-defined, but they are known to be critical in homeostasis, infection and inflammation at other mucosal barriers, such as the gut. Moreover, they are important players in the IL17/IL22 axis, which is key to lung health. In this review, we discuss the emerging role of ILC3s in the context of infectious and inflammatory lung diseases, with a focus on data from human subjects.
| Type: | Article |
|---|---|
| Title: | Type 3 ILCs in Lung Disease |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fimmu.2019.00092 |
| Publisher version: | https://doi.org/10.3389/fimmu.2019.00092 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Immunology, ILC3, lung disease, pnemonia, tuberulosis, COPD, airway hypersensitivity, pulmonary fibrosis, INNATE LYMPHOID-CELLS, GAMMA-DELTA T, STIMULATING FACTOR EXPRESSION, TISSUE HOMEOSTASIS, BRONCHIAL-MUCOSA, IMMUNE-RESPONSE, HOST-DEFENSE, IL-22, INFLAMMATION, INFECTION |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10073054 |
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