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Suspension and Mixing Characterization of Intermittent Agitation Modes in DASGIP Bioreactors

Samaras, J; Micheletti, M; Ducci, A; (2019) Suspension and Mixing Characterization of Intermittent Agitation Modes in DASGIP Bioreactors. Chemical Engineering and Technology , 42 (8) pp. 1587-1593. 10.1002/ceat.201900069. Green open access

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Abstract

Intermittent agitation strategies have been increasingly used for a range of process development applications, i.e., to modulate physical cues, to improve stem cell differentiation yields, and to control hydrodynamic shear stresses in microcarrier suspension; however, there is a distinct lack of characterization. Both continuous and intermittent agitation modes in relation to suspension and mixing dynamics within a DASGIP bioreactor were characterized. Suspension dynamics were found to be affected by microcarrier porosity and the degree of settling was found to be more pronounced at the top of the bioreactor. Mixing time characterization showed a marked improvement in mixing efficiency for intermittent agitation, with an overall dependence on the timing of tracer insertion.

Type: Article
Title: Suspension and Mixing Characterization of Intermittent Agitation Modes in DASGIP Bioreactors
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/ceat.201900069
Publisher version: https://doi.org/10.1002/ceat.201900069
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Intermittent agitation, Mixing dynamics, Suspension dynamics, Bioreactor
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Biochemical Engineering
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10072957
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