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Invasive aspergillosis complicating treatment with tyrosine kinase inhibitors

Nasir, T; Lee, C; Lawrence, AS; Brown, JS; (2019) Invasive aspergillosis complicating treatment with tyrosine kinase inhibitors. BMJ Case Reports , 12 (1) 10.1136/bcr-2018-226121. Green open access

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Abstract

We describe three cases of pulmonary aspergillosis (PA) in three patients without traditional risk factors for invasive aspergillosis infection, such as prolonged neutropenia or high dose systemic corticosteroid therapy. All three patients developed PA whilst taking tyrosine kinase inhibitors (TKI) and sustained greater clinical improvement once TKI were withdrawn. Our case series supports the theory TKI treatment can increase susceptibility to PA without causing neutropenia. Recognition that TKI treatment may predispose to invasive aspergillosis will allow for rapid recognition of patients of affected patients and more effective management of future cases.

Type: Article
Title: Invasive aspergillosis complicating treatment with tyrosine kinase inhibitors
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1136/bcr-2018-226121
Publisher version: https://doi.org/10.1136/bcr-2018-226121
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10072816
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