Hall, N;
Drewett, M;
Burge, D;
Eaton, S;
(2019)
Growth pattern of infants with gastroschisis in the neonatal period.
Clinical nutrition ESPEN
, 32
pp. 82-87.
10.1016/j.clnesp.2019.04.008.
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Abstract
Background / Aim: Early postnatal growth patterns may have significant long term health effects. Although preterm infants on parenteral nutrition (PN) exhibit poor growth, growth pattern of term or near-term infants requiring PN is not well repo rted. We aimed to investigate this in infants born with gastroschisis. Methods: Retrospective review of all infants with gastroschisis requiring PN treated at a single centre over a 4 year period. Growth and clinical data were retrieved, and weigh t SDS scores for corrected gestational age calculated. Weight SDS (mean±SD) were compared at clinically relevant timepoints and multi-level regression used to model growth trends over time. Main Results: During the study period 61 infants with gas troschisis were treated; all were included. Infants were small for gestational age at birth for weight (SDS score -0.87±0.85). Weight SDS decreased significantly during the first 10 days of age (mean decrease 0.81±0.56; p<0.0001) and between birth and discharge (mean decrease 0.81±0.56; p<0.0001). Despite tolerating full enteral feeds, weight SDS velocity was negative around the time of transition from parenteral to enteral feed. There was evidence of ‘catch up’ growth between 3 and 6 months of age. Conclusion: Despite nutritional support with PN, infants with gastroschisis demonstrate significant growth failure during the newborn period. Further efforts are required to understand the underlying mechanisms, improve nutritional support and to evaluate the long term consequences of postnatal growth failure in this population.
| Type: | Article |
|---|---|
| Title: | Growth pattern of infants with gastroschisis in the neonatal period |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.clnesp.2019.04.008 |
| Publisher version: | https://doi.org/10.1016/j.clnesp.2019.04.008 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10072702 |
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