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Diffusion MRI of white matter microstructure development in childhood and adolescence: Methods, challenges and progress

Tamnes, CK; Roalf, DR; Goddings, A-L; Lebel, C; (2018) Diffusion MRI of white matter microstructure development in childhood and adolescence: Methods, challenges and progress. Developmental Cognitive Neuroscience , 33 pp. 161-175. 10.1016/j.dcn.2017.12.002. Green open access

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Abstract

Diffusion magnetic resonance imaging (dMRI) continues to grow in popularity as a useful neuroimaging method to study brain development, and longitudinal studies that track the same individuals over time are emerging. Over the last decade, seminal work using dMRI has provided new insights into the development of brain white matter (WM) microstructure, connections and networks throughout childhood and adolescence. This review provides an introduction to dMRI, both diffusion tensor imaging (DTI) and other dMRI models, as well as common acquisition and analysis approaches. We highlight the difficulties associated with ascribing these imaging measurements and their changes over time to specific underlying cellular and molecular events. We also discuss selected methodological challenges that are of particular relevance for studies of development, including critical choices related to image acquisition, image analysis, quality control assessment, and the within-subject and longitudinal reliability of dMRI measurements. Next, we review the exciting progress in the characterization and understanding of brain development that has resulted from dMRI studies in childhood and adolescence, including brief overviews and discussions of studies focusing on sex and individual differences. Finally, we outline future directions that will be beneficial to the field.

Type: Article
Title: Diffusion MRI of white matter microstructure development in childhood and adolescence: Methods, challenges and progress
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.dcn.2017.12.002
Publisher version: https://doi.org/10.1016/j.dcn.2017.12.002
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Keywords: Brain development, DTI, Longitudinal, Maturation, Neuroimaging, White matter, Diffusion Magnetic Resonance Imaging, Humans, Neuroimaging, White Matter
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Population, Policy and Practice Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10072413
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