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Obesity and Atrial Fibrillation: Epidemiology, Pathophysiology and Novel Therapeutic Opportunities

Vyas, V; Lambiase, P; (2019) Obesity and Atrial Fibrillation: Epidemiology, Pathophysiology and Novel Therapeutic Opportunities. Arrhythmia & Electrophysiology Review , 8 (1) pp. 28-36. 10.15420/aer.2018.76.2. Green open access

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Abstract

Obesity is already a major global public health issue, implicated in a vast array of conditions affecting multiple body systems. It is now also firmly established as an independent risk factor in the incidence and progression of AF. The rapidly rising morbidity, mortality and healthcare costs associated with AF despite implementation of the three pillars of AF management - anticoagulation, rate control and rhythm control - suggest other strategies need to be considered. Compelling data has unveiled novel insights into adipose tissue biology and its effect on arrhythmogenesis while secondary prevention strategies targeting obesity as part of a comprehensive risk factor management programme have been demonstrated to be highly effective. Here, the authors review the epidemiological basis of the obesity-AF relationship, consider its underlying pathophysiology and discuss new therapeutic opportunities on the horizon.

Type: Article
Title: Obesity and Atrial Fibrillation: Epidemiology, Pathophysiology and Novel Therapeutic Opportunities
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.15420/aer.2018.76.2
Publisher version: https://doi.org/10.15420/aer.2018.76.2
Language: English
Additional information: This work is open access under the CC-BY-NC 4.0 License which allows users to copy, redistribute and make derivative works for non-commercial purposes, provided the original work is cited correctly. See here for more info: https://creativecommons.org/licenses/by-nc/4.0/legalcode
Keywords: Atrial fibrillation, adiposity, epicardial fat, obesity, obesity paradox, risk factor management
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Clinical Science
URI: https://discovery.ucl.ac.uk/id/eprint/10072352
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