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Development and Characterization of Gallium-Doped Bioactive Glasses for Potential Bone Cancer Applications

Rana, KS; Souza, LPD; Isaacs, MA; Raja, FNS; Morrell, AP; Martin, RA; (2017) Development and Characterization of Gallium-Doped Bioactive Glasses for Potential Bone Cancer Applications. ACS Biomaterials Science and Engineering , 3 (12) pp. 3425-3432. 10.1021/acsbiomaterials.7b00283. Green open access

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Abstract

In this study, we have developed a series of novel gallium oxide doped bioactive glasses to specifically target osteosarcoma cells while aiding new bone formation. The results show that osteosarcoma (Saos-2) cell death is induced through the addition of gallium oxide. Relative to the gallium-free control glass (0% Ga) glasses containing 1, 2, and 3% Ga decreased Saos-2 cell viability in a dose dependent manner. After 72 h in media preconditioned with 3% Ga Saos-2 cell viability was reduced by over 50%. Corresponding studies undertaken on primary normal human osteoblast cells (NHOst) demonstrated no adverse effects to the gallium containing glasses. Hydroxyapatite formation was observed for all glasses when exposed to simulated body fluid.

Type: Article
Title: Development and Characterization of Gallium-Doped Bioactive Glasses for Potential Bone Cancer Applications
Open access status: An open access version is available from UCL Discovery
DOI: 10.1021/acsbiomaterials.7b00283
Publisher version: https://doi.org/10.1021/acsbiomaterials.7b00283
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Apatite; bioactive glass; bone; cancer; gallium; sarcoma
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/10072339
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