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Cellular-level understanding of supraspinal control: what can be learned from zebrafish?

Lau, JY; Bianco, IH; Severi, KE; (2019) Cellular-level understanding of supraspinal control: what can be learned from zebrafish? Current Opinion in Physiology , 8 pp. 141-145. 10.1016/j.cophys.2019.01.013. Green open access

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Abstract

Electrical stimulation of various brainstem nuclei has revealed sites capable of initiating and modulating locomotion. However, subsequent experiments have revealed that these regions are functionally heterogeneous. Modern techniques including molecular-genetic methods to label cell types and optogenetic approaches to manipulate neural activity are now enabling functional examination at the cellular level. In this review, we will highlight recent work revealing distinct roles for neurons of defined neurotransmitter identity and show how comparisons across species can stimulate new experimental and analytical approaches to further our understanding of how supraspinal populations function at a cellular level to control precise aspects of behaviour.

Type: Article
Title: Cellular-level understanding of supraspinal control: what can be learned from zebrafish?
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.cophys.2019.01.013
Publisher version: https://doi.org/10.1016/j.cophys.2019.01.013
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: https://discovery.ucl.ac.uk/id/eprint/10072181
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