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Multimodal use of the porphyrin TMPyP: From cancer therapy to antimicrobial applications

Garcia-Sampedro, A; Tabero, A; Mahamed, I; Acedo, P; (2019) Multimodal use of the porphyrin TMPyP: From cancer therapy to antimicrobial applications. Journal of Porphyrins and Phthalocyanines , 23 (1-2) pp. 11-27. 10.1142/S1088424619500111. Green open access

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Abstract

The cationic porphyrin meso-tetra(4-N-methylpyridyl)porphine (TMPyP) has a high yield of singlet oxygen generation upon light activation and a strong affinity for DNA. These advantageous properties have turned it into a promising photosensitizer for use in photodynamic therapy (PDT). In this review, we have summarized the current state-of-the-art applications of TMPyP for the treatment of cancer as well as its implementation in antimicrobial PDT. The most relevant studies reporting its pharmacokinetics, subcellular localization, mechanism of action, tissue biodistribution and dosimetry are discussed. Combination strategies using TMPyP-PDT together with other photosensitizers and chemotherapeutic agents to achieve synergistic anti-tumor effects and reduce resistance to therapy are also explored. Finally, we have addressed emerging applications of this porphyrin, including nanoparticle-mediated delivery, controlled drug release, biosensing and G-quadruplex stabilization for tumor growth inhibition. Altogether, this work highlights the great potential and versatility that TMPyP can offer in different fields of biomedicine such us cancer treatment or antimicrobial therapy.

Type: Article
Title: Multimodal use of the porphyrin TMPyP: From cancer therapy to antimicrobial applications
Open access status: An open access version is available from UCL Discovery
DOI: 10.1142/S1088424619500111
Publisher version: http://doi.org/10.1142/S1088424619500111
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: porphyrins, photodynamic therapy, antimicrobial inactivation, reactive oxygen species, combination therapy, nanoparticles
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth
URI: https://discovery.ucl.ac.uk/id/eprint/10072128
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