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Impact of post mastectomy radiotherapy on the silicone breast implant

Magill, LJ; Ricketts, K; Keshtgar, M; Mosahebi, A; Jell, G; (2019) Impact of post mastectomy radiotherapy on the silicone breast implant. Materials Science and Engineering: C , 98 pp. 288-292. 10.1016/j.msec.2018.12.047. Green open access

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Abstract

Implant based reconstruction accounts for over half of breast reconstruction performed in the UK. Patients with implant based breast reconstructions undergoing post mastectomy radiotherapy are at increased risk of capsular contracture and reconstructive failure. This study sought to determine the effect of treatment dose radiotherapy on the bulk mechanical, surface chemical properties of silicone implants as well as their cellular response. Silicone breast implant shells were submitted to treatment dose radiotherapy, 2.67 Gy (one daily fraction) and 40.05 Gy (15 fractions) using non-irradiated shells as controls. Bulk mechanical and surface chemical properties of the shells were evaluated using tensile and tear testing, attenuated total reflectance – fourier transform infrared spectroscopy (ATR-FTIR), water contact angle measurements. HDFa cells were seeded on the shells and Alamar Blue assay was performed to study cell metabolic activity. Cell morphology was evaluated using phalloidin and DAPI staining. There was no significant difference in tensile, tear strength and Young's modulus however there was reduction in maximum elongation following irradiation. Irradiation of the shells did not significant alter spectroscopy measurements nor wettability of the shells. Cell metabolism was not significantly affected by irradiation. Further analysis is warranted of the micromechanical properties to fully elucidate the effect of irradiation on the breast implant which could explain the increased rate of capsular contracture and reconstructive failure in patients undergoing post-mastectomy radiotherapy.

Type: Article
Title: Impact of post mastectomy radiotherapy on the silicone breast implant
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.msec.2018.12.047
Publisher version: https://doi.org/10.1016/j.msec.2018.12.047
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Technology, Materials Science, Biomaterials, Materials Science, Post mastectomy radiation therapy, Breast implant, Silicone implant, Breast reconstruction, Failure, POSTMASTECTOMY RADIATION-THERAPY, CAPSULAR CONTRACTURE, ADJUVANT RADIOTHERAPY, PATIENT SATISFACTION, PREMENOPAUSAL WOMEN, RECONSTRUCTION, OUTCOMES, CANCER, TISSUE, TRENDS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Targeted Intervention
URI: https://discovery.ucl.ac.uk/id/eprint/10072040
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