UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Mapping cortical surface features in treatment resistant schizophrenia with in vivo structural MRI

Barry, EF; Vanes, LD; Andrews, DS; Patel, K; Horne, CM; Mouchlianitis, E; Hellyer, PJ; (2019) Mapping cortical surface features in treatment resistant schizophrenia with in vivo structural MRI. Psychiatry Research , 274 pp. 335-344. 10.1016/j.psychres.2019.02.028.

[img] Text
Vanes Barry_PsychiatryResearch_accepted.pdf - Accepted version
Access restricted to UCL open access staff until 15 February 2020.

Download (589kB)

Abstract

Decreases in cortical volume (CV), thickness (CT) and surface area (SA) have been reported in individuals with schizophrenia by in vivo MRI studies. However, there are few studies that examine these cortical measures as potential biomarkers of treatment resistance (TR) and treatment response (NTR) in schizophrenia. This study used structural MRI to examine differences in CV, CT, and SA in 42 adults with schizophrenia (TR = 21, NTR = 21) and 23 healthy controls (HC) to test the hypothesis that individuals with TR schizophrenia have significantly greater reductions in these cortical measures compared to individuals with NTR schizophrenia. We found that individuals with TR schizophrenia showed significant reductions in CV and CT compared to individuals with NTR schizophrenia in right frontal and precentral regions, right parietal and occipital cortex, left temporal cortex and bilateral cingulate cortex. In line with previous literature, the temporal lobe and cingulate gyrus in both patient groups showed significant reductions of all three measures when compared to healthy controls. Taken together these results suggest that regional changes in CV and CT may index mechanisms specific to TR schizophrenia and potentially identify patients with TR schizophrenia for earlier treatment.

Type: Article
Title: Mapping cortical surface features in treatment resistant schizophrenia with in vivo structural MRI
Location: Ireland
DOI: 10.1016/j.psychres.2019.02.028
Publisher version: https://doi.org/10.1016/j.psychres.2019.02.028
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Cortical thickness, Cortical volume, MRI, Schizophrenia, Treatment resistant
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/10072039
Downloads since deposit
1Download
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item