Femminella, GD;
Bencivenga, L;
Petraglia, L;
Visaggi, L;
Gioia, L;
Grieco, FV;
de Lucia, C;
... Ferrara, N; + view all
(2017)
Antidiabetic Drugs in Alzheimer's Disease: Mechanisms of Action and Future Perspectives.
Journal of Diabetes Research
, Article 7420796. 10.1155/2017/7420796.
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Abstract
Diabetes mellitus (DM) and Alzheimer’s disease (AD) are two highly prevalent conditions in the elderly population and major public health burden. In the past decades, a pathophysiological link between DM and AD has emerged and central nervous system insulin resistance might play a significant role as a common mechanism; however, other factors such as inflammation and oxidative stress seem to contribute to the shared pathophysiological link. Both preclinical and clinical studies have evaluated the possible neuroprotective mechanisms of different classes of antidiabetic medications in AD, with some promising results. Here, we review the evidence on the mechanisms of action of antidiabetic drugs and their potential use in AD.
| Type: | Article |
|---|---|
| Title: | Antidiabetic Drugs in Alzheimer's Disease: Mechanisms of Action and Future Perspectives |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1155/2017/7420796 |
| Publisher version: | https://doi.org/10.1155/2017/7420796 |
| Language: | English |
| Additional information: | © 2017 Grazia Daniela Femminella et al. This is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10072003 |
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