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Antidiabetic Drugs in Alzheimer's Disease: Mechanisms of Action and Future Perspectives

Femminella, GD; Bencivenga, L; Petraglia, L; Visaggi, L; Gioia, L; Grieco, FV; de Lucia, C; ... Ferrara, N; + view all (2017) Antidiabetic Drugs in Alzheimer's Disease: Mechanisms of Action and Future Perspectives. Journal of Diabetes Research , Article 7420796. 10.1155/2017/7420796. Green open access

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Abstract

Diabetes mellitus (DM) and Alzheimer’s disease (AD) are two highly prevalent conditions in the elderly population and major public health burden. In the past decades, a pathophysiological link between DM and AD has emerged and central nervous system insulin resistance might play a significant role as a common mechanism; however, other factors such as inflammation and oxidative stress seem to contribute to the shared pathophysiological link. Both preclinical and clinical studies have evaluated the possible neuroprotective mechanisms of different classes of antidiabetic medications in AD, with some promising results. Here, we review the evidence on the mechanisms of action of antidiabetic drugs and their potential use in AD.

Type: Article
Title: Antidiabetic Drugs in Alzheimer's Disease: Mechanisms of Action and Future Perspectives
Open access status: An open access version is available from UCL Discovery
DOI: 10.1155/2017/7420796
Publisher version: https://doi.org/10.1155/2017/7420796
Language: English
Additional information: © 2017 Grazia Daniela Femminella et al. This is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/).
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Institute of Cognitive Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/10072003
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