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Re-evaluating Circuit Mechanisms Underlying Pattern Separation

Cayco-Gajic, NA; Silver, RA; (2019) Re-evaluating Circuit Mechanisms Underlying Pattern Separation. [Review]. Neuron , 101 (4) pp. 584-602. 10.1016/j.neuron.2019.01.044. Green open access

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Abstract

When animals interact with complex environments, their neural circuits must separate overlapping patterns of activity that represent sensory and motor information. Pattern separation is thought to be a key function of several brain regions, including the cerebellar cortex, insect mushroom body, and dentate gyrus. However, recent findings have questioned long-held ideas on how these circuits perform this fundamental computation. Here, we re-evaluate the functional and structural mechanisms underlying pattern separation. We argue that the dimensionality of the space available for population codes representing sensory and motor information provides a common framework for understanding pattern separation. We then discuss how these three circuits use different strategies to separate activity patterns and facilitate associative learning in the presence of trial-to-trial variability.

Type: Article
Title: Re-evaluating Circuit Mechanisms Underlying Pattern Separation
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neuron.2019.01.044
Publisher version: https://doi.org/10.1016/j.neuron.2019.01.044
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: https://discovery.ucl.ac.uk/id/eprint/10071966
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