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Characterization of paralogous uncx transcription factor encoding genes in zebrafish

Nittoli, V; Fortunato, AE; Fasano, G; Coppola, U; Gentile, A; Maiella, S; Langellotto, F; ... Sordino, P; + view all (2019) Characterization of paralogous uncx transcription factor encoding genes in zebrafish. Gene: X , 2 , Article 100011. 10.1016/j.gene.2019.100011. Green open access

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Abstract

The paired-type homeodomain transcription factor Uncx is involved in multiple processes of embryogenesis in vertebrates. Reasoning that zebrafish genes uncx4.1 and uncx are orthologs of mouse Uncx, we studied their genomic environment and developmental expression. Evolutionary analyses indicate the zebrafish uncx genes as being paralogs deriving from teleost-specific whole-genome duplication. Whole-mount in situ mRNA hybridization of uncx transcripts in zebrafish embryos reveals novel expression domains, confirms those previously known, and suggests sub-functionalization of paralogs. Using genetic mutants and pharmacological inhibitors, we investigate the role of signaling pathways on the expression of zebrafish uncx genes in developing somites. In identifying putative functional role(s) of zebrafish uncx genes, we hypothesized that they encode transcription factors that coordinate growth and innervation of somitic muscles.

Type: Article
Title: Characterization of paralogous uncx transcription factor encoding genes in zebrafish
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.gene.2019.100011
Publisher version: http://doi.org/10.1016/j.gene.2019.100011
Language: English
Additional information: Copyright © 2019 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/).
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: https://discovery.ucl.ac.uk/id/eprint/10071920
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