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Diagnostic and prognostic biomarkers in cholangiocarcinoma

Macias, RIR; Kornek, M; Rodrigues, PM; Paiva, NA; Castro, RE; Urban, S; Pereira, SP; ... Banales, JM; + view all (2019) Diagnostic and prognostic biomarkers in cholangiocarcinoma. Liver International , 39 (S1) pp. 108-122. 10.1111/liv.14090. Green open access

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Abstract

The high mortality rate of cholangiocarcinoma (CCA) is due, in part, to the lack of non‐invasive approaches able to accurately detect this silent tumour at early stages, when therapeutic options can be potentially curative or may at least increase the overall survival of patients. The fact that the majority of CCA tumours are not linked to any known aetiological factor highly compromises the monitoring of patients at risk for tumour development and also their early diagnosis. Combination of clinical/biochemical features, imaging techniques and analysis of non‐specific tumour biomarkers in serum are commonly used to help in the diagnosis of CCA, but tumour biopsy is usually required to confirm the diagnosis. Moreover, no prognostic biomarkers are currently used in the clinical setting, deserving more innovative research, and international validation and consensus. Important efforts have been made in the last years to identify new accurate non‐invasive biomarkers, by using innovative techniques and high‐throughput omics technologies. This review summarises and discusses the advances in the investigation of novel diagnostic and prognostic biomarkers in CCA and envisions the future directions in this field of research.

Type: Article
Title: Diagnostic and prognostic biomarkers in cholangiocarcinoma
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/liv.14090
Publisher version: https://doi.org/10.1111/liv.14090
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: CCA prognosis, biliary cancer, biomarker, early diagnosis, omics
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth
URI: https://discovery.ucl.ac.uk/id/eprint/10071778
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