Moran, I;
Avery, DT;
Payne, K;
Lenthall, H;
Davies, EG;
Burns, S;
Ip, W;
... Phan, TG; + view all
(2019)
B cell–intrinsic requirement for STK4 in humoral immunity in mice and human subjects.
Journal of Allergy and Clinical Immunology
, 143
(6)
pp. 2302-2305.
10.1016/j.jaci.2019.02.010.
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Burns_STK4 resubmitted JACI-D-19-00027_R1_extracted.pdf - Accepted Version Download (3MB) | Preview |
Abstract
Humoral immune defects are described in 9 patients from 5 families with STK4 deficiency. A mouse model carrying the novel p.Y88del show that these defects are intrinsic to the B cells.
| Type: | Article |
|---|---|
| Title: | B cell–intrinsic requirement for STK4 in humoral immunity in mice and human subjects |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.jaci.2019.02.010 |
| Publisher version: | https://doi.org/10.1016/j.jaci.2019.02.010 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | CRISPR/Cas9, STK4 deficiency, combined immunodeficiency disease, germinal centre, humoral immunity, memory B cells, mouse model, plasma cells |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10071752 |
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