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B cell–intrinsic requirement for STK4 in humoral immunity in mice and human subjects

Moran, I; Avery, DT; Payne, K; Lenthall, H; Davies, EG; Burns, S; Ip, W; ... Phan, TG; + view all (2019) B cell–intrinsic requirement for STK4 in humoral immunity in mice and human subjects. Journal of Allergy and Clinical Immunology , 143 (6) pp. 2302-2305. 10.1016/j.jaci.2019.02.010. Green open access

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Abstract

Humoral immune defects are described in 9 patients from 5 families with STK4 deficiency. A mouse model carrying the novel p.Y88del show that these defects are intrinsic to the B cells.

Type: Article
Title: B cell–intrinsic requirement for STK4 in humoral immunity in mice and human subjects
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.jaci.2019.02.010
Publisher version: https://doi.org/10.1016/j.jaci.2019.02.010
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: CRISPR/Cas9, STK4 deficiency, combined immunodeficiency disease, germinal centre, humoral immunity, memory B cells, mouse model, plasma cells
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
URI: https://discovery.ucl.ac.uk/id/eprint/10071752
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