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A domestication history of dynamic adaptation and genomic deterioration in sorghum

Smith, O; Nicholson, WV; Kistler, L; Mace, E; Clapham, A; Rose, P; Stevens, C; ... Allaby, RG; + view all (2019) A domestication history of dynamic adaptation and genomic deterioration in sorghum. Nature Plants , 5 pp. 369-379. 10.1038/s41477-019-0397-9. Green open access

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Abstract

The evolution of domesticated cereals was a complex interaction of shifting selection pressures and repeated episodes of introgression. Genomes of archaeological crops have the potential to reveal these dynamics without being obscured by recent breeding or introgression. We report a temporal series of archaeogenomes of the crop sorghum (Sorghum bicolor) from a single locality in Egyptian Nubia. These data indicate no evidence for the effects of a domestication bottleneck, but instead reveal a steady decline in genetic diversity over time coupled with an accumulating mutation load. Dynamic selection pressures acted sequentially to shape architectural and nutritional domestication traits and to facilitate adaptation to the local environment. Later introgression between sorghum races allowed the exchange of adaptive traits and achieved mutual genomic rescue through an ameliorated mutation load. These results reveal a model of domestication in which genomic adaptation and deterioration were not focused on the initial stages of domestication but occurred throughout the history of cultivation.

Type: Article
Title: A domestication history of dynamic adaptation and genomic deterioration in sorghum
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41477-019-0397-9
Publisher version: https://doi.org/10.1038/s41477-019-0397-9
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL SLASH
UCL > Provost and Vice Provost Offices > UCL SLASH > Faculty of S&HS
UCL > Provost and Vice Provost Offices > UCL SLASH > Faculty of S&HS > Institute of Archaeology
UCL > Provost and Vice Provost Offices > UCL SLASH > Faculty of S&HS > Institute of Archaeology > Institute of Archaeology Gordon Square
URI: https://discovery.ucl.ac.uk/id/eprint/10071644
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