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Heart Regeneration in the Mexican Cavefish

Stockdale, WT; Lemieux, ME; Killen, AC; Zhao, J; Hu, Z; Riepsaame, J; Hamilton, N; ... Mommersteeg, MTM; + view all (2018) Heart Regeneration in the Mexican Cavefish. Cell Reports , 25 (8) 1997-2007.e7. 10.1016/j.celrep.2018.10.072. Green open access

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Abstract

Although Astyanax mexicanus surface fish regenerate their hearts after injury, their Pachón cave-dwelling counterparts cannot and, instead, form a permanent fibrotic scar, similar to the human heart. Myocardial proliferation peaks at similar levels in both surface fish and Pachón 1 week after injury. However, in Pachón, this peak coincides with a strong scarring and immune response, and ultimately, cavefish cardiomyocytes fail to replace the scar. We identified lrrc10 to be upregulated in surface fish compared with Pachón after injury. Similar to cavefish, knockout of lrrc10 in zebrafish impairs heart regeneration without affecting wound cardiomyocyte proliferation. Furthermore, using quantitative trait locus (QTL) analysis, we have linked the degree of heart regeneration to three loci in the genome, identifying candidate genes fundamental to the difference between scarring and regeneration. Our study provides evidence that successful heart regeneration entails a delicate interplay between cardiomyocyte proliferation and scarring.

Type: Article
Title: Heart Regeneration in the Mexican Cavefish
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.celrep.2018.10.072
Publisher version: https://doi.org/10.1016/j.celrep.2018.10.072
Language: English
Additional information: Copyright © 2018 The Author(s) This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: Mexican cavefish, heart regeneration, fibrotic scar, QTL, myocardial proliferation, lrrc10
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: https://discovery.ucl.ac.uk/id/eprint/10071499
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