Zanini, D;
Giraldo, D;
Warren, B;
Katana, R;
Andrés, M;
Reddy, S;
Pauls, S;
... Göpfert, MC; + view all
(2018)
Proprioceptive Opsin Functions in Drosophila Larval Locomotion.
Neuron
, 98
(1)
67-74.e4.
10.1016/j.neuron.2018.02.028.
Preview |
Text
Andres Miguel_MS.pdf - Accepted Version Download (956kB) | Preview |
Abstract
Animals rely on mechanosensory feedback from proprioceptors to control locomotory body movements. Unexpectedly, we found that this movement control requires visual opsins. Disrupting the Drosophila opsins NINAE or Rh6 impaired larval locomotion and body contractions, independently of light and vision. Opsins were detected in chordotonal proprioceptors along the larval body, localizing to their ciliated dendrites. Loss of opsins impaired mechanically evoked proprioceptor spiking and cilium ultrastructure. Without NINAE or Rh6, NOMPC mechanotransduction channels leaked from proprioceptor cilia and ciliary Inactive (Iav) channels partly disappeared. Locomotion is shown to require opsins in proprioceptors, and the receptors are found to express the opsin gene Rh7, in addition to ninaE and Rh6. Besides implicating opsins in movement control, this documents roles of non-ciliary, rhabdomeric opsins in cilium organization, providing a model for a key transition in opsin evolution and suggesting that structural roles of rhabdomeric opsins preceded their use for light detection.
| Type: | Article |
|---|---|
| Title: | Proprioceptive Opsin Functions in Drosophila Larval Locomotion |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.neuron.2018.02.028 |
| Publisher version: | https://doi.org/10.1016/j.neuron.2018.02.028 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | chordotonal organcilium maintenance, Inactive (Iav) channel, mechanosensory transduction, movement contro, lNanchung (Nan), NOMPC, rhabdomeric opsin evolution, sensory dendrite organization, TRP cation channel |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > The Ear Institute |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10071440 |
Archive Staff Only
 |
View Item |
