Campagner, D;
Evans, MH;
Chlebikova, K;
Colins-Rodriguez, A;
Loft, MSE;
Fox, S;
Pettifer, D;
... Petersen, RS; + view all
(2019)
Prediction of choice from competing mechanosensory and choice-memory cues during active tactile decision making.
Journal of Neuroscience
, 39
(20)
pp. 3921-3933.
10.1523/JNEUROSCI.2217-18.2019.
Preview |
Text
Campagner_3921.full.pdf Download (2MB) | Preview |
Abstract
Perceptual decision making is an active process where animals move their sense organs to extract task-relevant information. To investigate how the brain translates sensory input into decisions during active sensation, we developed a mouse active touch task where the mechanosensory input can be precisely measured and that challenges animals to use multiple mechanosensory cues. Male mice were trained to localise a pole using a single whisker and to report their decision by selecting one of three choices. Using high-speed imaging and machine vision we estimated whisker-object mechanical forces at millisecond resolution. Mice solved the task by a sensory-motor strategy where both the strength and direction of whisker bending were informative cues to pole location. We found competing influences of immediate sensory input and choice memory on mouse choice. On correct trials, choice could be predicted from the direction and strength of whisker bending, but not from previous choice. In contrast, on error trials, choice could be predicted from previous choice but not from whisker bending. This study shows that animal choices during active tactile decision making can be predicted from mechanosenory and choice-memory signals; and provides a new task, well-suited for future study of the neural basis of active perceptual decisions.
| Type: | Article |
|---|---|
| Title: | Prediction of choice from competing mechanosensory and choice-memory cues during active tactile decision making |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1523/JNEUROSCI.2217-18.2019 |
| Publisher version: | https://doi.org/10.1523/JNEUROSCI.2217-18.2019 |
| Language: | English |
| Additional information: | Copyright © 2019 Campagner et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > The Sainsbury Wellcome Centre |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10071421 |
Archive Staff Only
 |
View Item |
