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Getting close. Lysosome-ER contact sites tailor Ca²⁺ signals

Patel, S; (2019) Getting close. Lysosome-ER contact sites tailor Ca²⁺ signals. Cell Calcium , 80 pp. 194-196. 10.1016/j.ceca.2019.02.003. Green open access

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Abstract

Inter-organelle communication is critical for the generation of complex Ca2+ signals. A recent study by Atakpa et al provides evidence that membrane contact sites between lysosomes and the ER facilitate lysosomal Ca2+ uptake to shape cytosolic Ca2+ signals derived from the ER.

Type: Article
Title: Getting close. Lysosome-ER contact sites tailor Ca²⁺ signals
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ceca.2019.02.003
Publisher version: https://doi.org/10.1016/j.ceca.2019.02.003
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: IP3 receptors, Lysosomes, Endoplasmic reticulum, Membrane contact sites, Ca2+ uptake
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: https://discovery.ucl.ac.uk/id/eprint/10071419
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