Southern, P;
Pankhurst, QA;
(2019)
Using the 'dispersion-retention-formulation method' to estimate clinical and preclinical dosage limits for interstitial nanomedicines or agents.
Journal of Magnetism and Magnetic Materials
, 473
pp. 74-78.
10.1016/j.jmmm.2018.10.019.
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Abstract
We propose the “DRF method” for estimating dosage limits for interstitially administered therapeutic or diagnostic nanomedicines or agents from three characteristic parameters that can be experimentally determined from in vivo data. These are: (i) the dispersion of the injected fluid around the injection site; (ii) the retention of the injected fluid at the injection site; and (iii) the formulation characteristics of the fluid with respect to local and systemic tolerability. We present formulae that allow dose-limit estimates to be made for any preclinical model, as well as for clinical studies. We illustrate the DRF method for the case of iron-oxide-based magnetic fluids, with reference to the published dose limits of regulatory-body-approved magnetic nanoparticles for MRI contrast enhancement, sentinel node detection, iron replacement therapy, and magnetic thermoablation.
| Type: | Article |
|---|---|
| Title: | Using the 'dispersion-retention-formulation method' to estimate clinical and preclinical dosage limits for interstitial nanomedicines or agents |
| Location: | Copenhagen, DENMARK |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.jmmm.2018.10.019 |
| Publisher version: | https://doi.org/10.1016/j.jmmm.2018.10.019 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Nanomedicines, Magnetic fluids, Magnetic nanoparticles, Interstitial administration |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10071251 |
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