UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Facile aqueous, room temperature preparation of high transverse relaxivity clustered iron oxide nanoparticles

Hobson, NJ; Weng, X; Ashford, M; Thanh, NTK; Schätzlein, AG; Uchegbu, IF; (2019) Facile aqueous, room temperature preparation of high transverse relaxivity clustered iron oxide nanoparticles. Colloids and Surfaces A: Physicochemical and Engineering Aspects , 570 pp. 165-171. 10.1016/j.colsurfa.2019.03.023. Green open access

[thumbnail of 1-s2.0-S0927775719302110-main.pdf]
Preview
Text
1-s2.0-S0927775719302110-main.pdf - Published Version

Download (3MB) | Preview

Abstract

Clustering superparamagnetic iron oxide nanoparticles (SPIONs) is one method of providing the biomedical benefits of larger SPIONs [e.g. superior T2 weighted magnetic resonance imaging (MRI) contrast] without increasing particle size. The work presented herein, describes the facile synthesis of clustered SPIONs that are suitable for MRI applications, by using a chitosan based polymer: N-palmitoyl-N-monomethyl-N-N-dimethyl-N-N-N-trimethyl-6-O-glycolchitosan (GCPQ) and aqueous nanoprecipitation followed by probe sonication, in the absence of organic solvents or elevated temperatures. The resulting clustered SPIONs consist of individual 8 nm iron oxide nanoparticles clustered into a 150 nm particle with a positive zeta potential (+23 mV) at neutral pH. X-ray diffraction confirms the presence of crystalline magnetic iron oxide, while magnetometer experiments show the clustered SPIONs are superparamagnetic giving an overall M s of 63.5 ± 1.3 emu g −1 . Relaxometry analyses revealed that the clustered SPIONs (inclusive of coatings) had a high r 2 value of 294.8 mM −1 s −1 and an r 2 /r 1 of 21.1 making the clustered SPIONs suitable for T2 weighted (negative) MRI contrast imaging applications. The resulting clustered SPIONs demonstrate that highly sensitive T2 contrast agents may be produced in mild room temperature conditions, without the need for organic solvents or low molecular weight surfactants.

Type: Article
Title: Facile aqueous, room temperature preparation of high transverse relaxivity clustered iron oxide nanoparticles
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.colsurfa.2019.03.023
Publisher version: https://doi.org/10.1016/j.colsurfa.2019.03.023
Language: English
Additional information: © 2019 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).
Keywords: SPIONs, Iron oxide nanoparticles, Superparamagnetic, GCPQ, N-palmitoyl-N-monomethyl-N,N-dimethylN,N,N-trimethyl-6-O-glycolchitosan, Chitosan, T2-weighted, Colloid, Relaxivity
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharma and Bio Chemistry
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Physics and Astronomy
URI: https://discovery.ucl.ac.uk/id/eprint/10071165
Downloads since deposit
156Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item