Wu, J; Williams, G; Niu, S; Gao, F; Tang, R; Zhu, L-M; (2019) A Multifunctional Biodegradable Nanocomposite for Cancer Theranostics. Advanced Science , 6 (14) , Article 1802001. 10.1002/advs.201802001.

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Abstract

Theranostic formulations, integrating both diagnostic and therapeutic functions into a single platform, hold great potential for precision medicines. In this work, we report a biodegradable nanoparticle-based theranostic based on hollow mesoporous organosilica nanoparticles (HMONs) for enhanced ultrasound (US)/photoacoustic (PA) dual-modality imaging guided chemo-photothermal therapy of cancer. The HMONs prepared were endowed with glutathione (GSH)-responsive biodegradation behavior by incorporating disulfide bonds into their framework. The nanoparticles were loaded with indocyanine green (ICG) and perfluoropentane (PFP). The former acts as a photothermal agent and the latter can generate bubbles for ultrasound imaging. A paclitaxel (PTX) prodrug was developed to both serve as a redox-sensitive gatekeeper controlling ICG release from the HMON pores and a chemotherapeutic. ICG generates mild hyperthermia upon exposure to an 808 nm laser, and this in turn leads to a liquid-gas phase transition of PFP, resulting in the generation of bubbles which can be used for ultrasound imaging. The platform is found to have excellent properties for both ultrasound and photoacoustic imaging. In addition, both in vitro and in vivo results showed the nanoparticles provide potent synergistic chemo-photothermal therapy. The novel material developed in this work thus has great potential for exploitation in advanced cancer therapies.

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