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Recent advances in fluoride-free aryne generation from arene precursors

Idiris, FIM; Jones, CR; (2017) Recent advances in fluoride-free aryne generation from arene precursors. [Review]. Organic and Biomolecular Chemistry , 15 (43) pp. 9044-9056. 10.1039/c7ob01947e. Green open access

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Abstract

Aryne chemistry has experienced a remarkable renaissance in recent years, with a significant increase in the synthetic applications reported for these highly valuable reactive intermediates. This resurgence of interest is in part due to the introduction of ortho-silylaryl triflates as precursors which can be activated under mild conditions using fluoride. Alternative fluoride-free strategies have received interest in the last decade, with a number of precursors to arynes and their activators reported. These approaches offer alternative modes of reactivity which prove, in some cases, to be orthogonal to those of ortho-silylaryl triflates. This review highlights some of the more recent fluoride-free methodologies developed to access aryne intermediates that start from arene-based precursors.

Type: Article
Title: Recent advances in fluoride-free aryne generation from arene precursors
Open access status: An open access version is available from UCL Discovery
DOI: 10.1039/c7ob01947e
Publisher version: http://doi.org/10.1039/c7ob01947e
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > SoP Pharmaceutical and Bio Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/10070986
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