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Tunable drug release from blend poly(vinyl pyrrolidone)-ethyl cellulose nanofibers

Williams, G; Godakanda, U; Li, H; Alquezar, L; Zhao, L; Zhu, L-M; de Silva, R; (2019) Tunable drug release from blend poly(vinyl pyrrolidone)-ethyl cellulose nanofibers. International Journal of Pharmaceutics , 562 pp. 172-179. 10.1016/j.ijpharm.2019.03.035. Green open access

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Abstract

The management of pain and inflammation arising from wounds is essential in obtaining effective healing rates. The application of a wound dressing loaded with an anti-inflammatory drug would enable both issues to be ameliorated, and the aim of this work was to fabricate such a dressing by electrospinning. Fibers comprising ethyl cellulose (EC) and poly(vinyl pyrrolidone) (PVP) loaded with naproxen (Nap) were developed to be used in the early stages of wound care. A family of PVP/EC/Nap systems was prepared by varying the PVP: EC ratio. In all cases, the products of electrospinning comprise non-woven mats of fibers which generally have smooth and cylindrical morphologies. The formulations exist as amorphous solid dispersions, and there appear to be intermolecular interactions between the three components. Adjusting the polymer ratios results in tunable drug release, and formulations have been produced which give zero-order drug release over 20 and 80 h. The fiber mats generated in this work thus have great potential to be used as dressings for the treatment of wound pain and inflammation.

Type: Article
Title: Tunable drug release from blend poly(vinyl pyrrolidone)-ethyl cellulose nanofibers
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ijpharm.2019.03.035
Publisher version: https://doi.org/10.1016/j.ijpharm.2019.03.035
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Naproxen, Wound dressing, Electrospinning, Poly(vinyl pyrrolidone), Ethyl cellulose
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics
URI: https://discovery.ucl.ac.uk/id/eprint/10070952
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