UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Gap junctions in liver disease: Implications for pathogenesis and therapy

Hernández-Guerra, M; Hadjihambi, A; Jalan, R; (2019) Gap junctions in liver disease: Implications for pathogenesis and therapy. Journal of Hepatology , 70 (4) pp. 759-772. 10.1016/j.jhep.2018.12.023. Green open access

[thumbnail of Jalan_JHEPAT-D-18-00958R1-11-53.pdf]
Preview
Text
Jalan_JHEPAT-D-18-00958R1-11-53.pdf - Accepted version

Download (1MB) | Preview

Abstract

In the normal liver, cells interact closely through gap junctions. By providing a pathway for the trafficking of low molecular mass molecules, these channels contribute to tissue homeostasis and maintenance of hepatic function. Thus, dysfunction of gap junctions affects a wide variety of liver processes, such as differentiation, cell death, inflammation and fibrosis. In fact, dysfunctional gap junctions have been implicated, for more than a decade, in cholestatic disease, hepatic cancer and cirrhosis. Additionally, in recent years there is an increasing body of evidence that these channels are also involved in other relevant and prevalent liver pathological processes, such as non-alcoholic fatty liver disease, acute liver injury and portal hypertension. In parallel to these new clinical implications the available data include controversial observations. Thus, a comprehensive overview is required to better understand the functional complexity of these pores. This paper will review the most recent knowledge concerning gap junction dysfunction, with a special focus on the role of these channels in the pathogenesis of relevant clinical entities and on potential therapeutic targets that are amenable to modification by drugs.

Type: Article
Title: Gap junctions in liver disease: Implications for pathogenesis and therapy
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.jhep.2018.12.023
Publisher version: https://doi.org/10.1016/j.jhep.2018.12.023
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Cirrhosis, Connexins, Gap junctions, Hemichannels, Intercellular communication, Liver
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth
URI: https://discovery.ucl.ac.uk/id/eprint/10070937
Downloads since deposit
24Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item