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YKL-40 is a CSF biomarker of intrathecal inflammation in secondary progressive multiple sclerosis

Burman, J; Raininko, R; Blennow, K; Zetterberg, H; Axelsson, M; Malmestrom, C; (2016) YKL-40 is a CSF biomarker of intrathecal inflammation in secondary progressive multiple sclerosis. Journal of Neuroimmunology , 292 pp. 52-57. 10.1016/j.jneuroim.2016.01.013. Green open access

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Abstract

YKL-40 (CHI3L1) is a glycoprotein predominantly produced by reactive astrocytes in chronic active MS lesions, which are common in secondary progressive MS. In this study, YKL-40 was investigated in different stages of MS and in relation to MRI findings. YKL-40 levels in CSF samples from two independent patient cohorts of MS patients were determined with ELISA. CSF YKL-40 was increased in patients with active relapsing–remitting MS and correlated with the number of gadolinium enhancing lesions. Patients with secondary progressive MS had similar high levels of YKL-40, whereas not active relapsing–remitting MS patients had YKL-40 levels comparable to healthy controls.

Type: Article
Title: YKL-40 is a CSF biomarker of intrathecal inflammation in secondary progressive multiple sclerosis
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.jneuroim.2016.01.013
Publisher version: http://doi.org/10.1016/j.jneuroim.2016.01.013
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Multiple sclerosis, SF, Biomarker, YKL-40, GFAp,sCD14, MRI
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10070758
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