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Real-Time fMRI Neurofeedback with War Veterans with Chronic PTSD: A Feasibility Study

Gerin, MI; Fichtenholtz, H; Roy, A; Walsh, CJ; Krystal, JH; Southwick, S; Hampson, M; (2016) Real-Time fMRI Neurofeedback with War Veterans with Chronic PTSD: A Feasibility Study. Frontiers in Neuroscience , 7 , Article 111. 10.3389/fpsyt.2016.00111. Green open access

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Abstract

Many patients with post-traumatic stress disorder (PTSD), especially war veterans, do not respond to available treatments. Here, we describe a novel neurofeedback (NF) intervention using real-time functional magnetic resonance imaging for treating and studying PTSD. The intervention involves training participants to control amygdala activity after exposure to personalized trauma scripts. Three combat veterans with chronic PTSD participated in this feasibility study. All three participants tolerated well the NF training. Moreover, two participants, despite the chronicity of their symptoms, showed clinically meaningful improvements, while one participant showed a smaller symptom reduction. Examination of changes in resting-state functional connectivity patterns revealed a normalization of brain connectivity consistent with clinical improvement. These preliminary results support feasibility of this novel intervention for PTSD and indicate that larger, well-controlled studies of efficacy are warranted.

Type: Article
Title: Real-Time fMRI Neurofeedback with War Veterans with Chronic PTSD: A Feasibility Study
Open access status: An open access version is available from UCL Discovery
DOI: 10.3389/fpsyt.2016.00111
Publisher version: http://dx.doi.org/10.3389/fpsyt.2016.00111
Language: English
Additional information: © 2016 Gerin, Fichtenholtz, Roy, Walsh, Krystal, Southwick and Hampson. This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/).
Keywords: PTSD, war veterans, neurofeedback, real-time fMRI, resting-state, functional connectivity
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/10070390
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