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The role of gut hormones in obesity

Mok, JK; Makaronidis, JM; Batterham, RL; (2019) The role of gut hormones in obesity. Current Opinion in Endocrine and Metabolic Research , 4 pp. 4-13. 10.1016/j.coemr.2018.09.005. Green open access

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Abstract

The worldwide obesity epidemic represents a severe threat to global health and is driving the scientific quest for a greater understanding of the mechanisms that regulate bodyweight, in order to develop effective preventative and therapeutic strategies. These research efforts have identified gut hormones as key regulators of energy and glucose homeostasis and have implicated them in the pathogenesis of obesity, the weight recidivism that frequently plagues dietary interventions and the marked changes in eating behaviour, weight reduction and metabolic benefits that accompany bariatric surgery. Consequently, therapeutic strategies aimed at modulating gut hormone levels or targeting their receptors are now being used to treat people with obesity and obesity-associated diseases, such as type 2 diabetes, and represent the most promising therapeutic avenue to combat the obesity epidemic.

Type: Article
Title: The role of gut hormones in obesity
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.coemr.2018.09.005
Publisher version: https://doi.org/10.1016/j.coemr.2018.09.005
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Gut hormones, Obesity, Obesity treatment, Weight loss, PYY, GLP-1
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Experimental and Translational Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10070379
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