UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Polypharmacy and drug–drug interactions in older and younger people living with HIV: the POPPY study

Halloran, MO; Boyle, C; Kehoe, B; Bagkeris, E; Mallon, P; Post, FA; Vera, J; ... Boffito, M; + view all (2019) Polypharmacy and drug–drug interactions in older and younger people living with HIV: the POPPY study. Antiviral Therapy 10.3851/IMP3293. (In press). Green open access

[img]
Preview
Text
Sabin_Polypharmacy and drug-drug interactions in older and younger people living with HIV. The POPPY study_AAM.pdf - Accepted version

Download (775kB) | Preview

Abstract

BACKGROUND: Polypharmacy (use of ≥ 5 medications) increases the risk of drug-drug interactions and can lead to negative health outcomes. This study aimed to review the medications of people living with HIV (PLWH) and HIV negative controls in the POPPY study and evaluate the frequency of polypharmacy and potential drug-drug interactions (PDDI). METHODS: Potential drug-drug interactions between non-antiretroviral (ARV) drugs were analysed using the Lexicomp® database, and PDDI between non-ARV and ARV drugs using the Liverpool drug interaction database. Between-group differences were assessed using Chi-squared, Mann-Whitney U and Kruskal Wallis tests. RESULTS: This analysis included 698 PLWH ≥50 years, 374 PLWH <50 years and 304 HIV-negative controls ≥50 years. The prevalence of polypharmacy was 65.8% in older PLWH, 48.1% in younger PLWH, and 13.2% in the HIV negative group. When ARVs were excluded 29.8% of older PLWH and 14.2% of younger PLWH had polypharmacy. The prevalence of ≥1 PDDI involving non-ARV drugs was 36.1%, 20.3% and 16.4% respectively in older PLWH, younger PLWH and HIV negative controls. In PLWH the prevalence of ≥1 PDDI involving ARV and non-ARV drugs was 57.3% in older PLWH and 32.4% in younger PLWH. CONCLUSIONS: Polypharmacy and PDDI involving non-ARV/ARV drugs and non-ARV/non-ARV drugs were common among older PLWH, highlighting the need for increased awareness and additional research on all types of PDDI.

Type: Article
Title: Polypharmacy and drug–drug interactions in older and younger people living with HIV: the POPPY study
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.3851/IMP3293
Publisher version: http://doi.org/10.3851/IMP3293
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Polypharmacy, Potential Drug-Drug Interactions, HIV, Aging
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health > Infection and Population Health
URI: https://discovery.ucl.ac.uk/id/eprint/10070372
Downloads since deposit
167Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item