UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Melanotic neuroectodermal tumour of infancy: A case report and differential diagnosis

Tan, AP; Jacques, TS; Mankad, K; James, G; Jeelani, O; Slater, O; D'Arco, F; (2018) Melanotic neuroectodermal tumour of infancy: A case report and differential diagnosis. The Neuroradiology Journal , 31 (4) pp. 434-439. 10.1177/1971400917741770. Green open access

[img]
Preview
Text
Tan et al.pdf - Accepted version

Download (26MB) | Preview

Abstract

Melanotic neuroectodermal tumour of infancy is an uncommon pigmented neoplasm of neural crest origin. It was first described in 1918 by Krompecher, known as congenital melanocarcinoma at that time. Although it is generally agreed upon that it is a benign entity, it is locally aggressive and has a significant recurrent risk, reported to be between 10-15%. There have also been prior reports of malignant behaviour in these tumours, although extremely rare. The majority of cases of this tumour (about 70%) arise from the maxilla and its occurrence in the cranial vault represents approximately 15.6% of cases. We describe a rare case of melanotic neuroectodermal tumour of infancy, with simultaneous involvement of the cranial vault and petrous temporal bone, in a four-month-old child, complicated by post-surgical pseudo-meningocele. This case illustrates the diagnostic dilemma in differentiating reactive osseous sclerosis from direct tumour infiltration, both of which can occur in the context of melanotic neuroectodermal tumour of infancy. The discussion places emphasis on differential diagnoses and useful radiological features to assist in clinching the diagnosis of melanotic neuroectodermal tumour of infancy.

Type: Article
Title: Melanotic neuroectodermal tumour of infancy: A case report and differential diagnosis
Open access status: An open access version is available from UCL Discovery
DOI: 10.1177/1971400917741770
Publisher version: https://doi.org/10.1177/1971400917741770
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Melanotic neuroectodermal tumour of infancy, cranial vault mass, pigmented neoplasm, pseudo-meningocele
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10070360
Downloads since deposit
34Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item