Alli-Balogun, GO;
Levine, TP;
(2019)
Regulation of targeting determinants in interorganelle communication.
Current Opinion in Cell Biology
, 57
pp. 106-114.
10.1016/j.ceb.2018.12.010.
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Abstract
The field of interorganelle communication is now established as a major aspect of intracellular organisation, with a profusion of material and signals exchanged between organelles. One way to address interorganelle communication is to study the interactions of the proteins involved, particularly targeting interactions, which are a key way to regulate activity. While most peripheral membrane proteins have single determinants for membrane targeting, proteins involved in interorganelle communication have more than one such determinant, sometimes as many as four, as in Vps13. Here we review the targeting determinants, showing how they can be relatively hard to find, how they are regulated, and how proteins integrate information from multiple targeting determinants.
| Type: | Article |
|---|---|
| Title: | Regulation of targeting determinants in interorganelle communication |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.ceb.2018.12.010 |
| Publisher version: | https://doi.org/10.1016/j.ceb.2018.12.010 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | membrane contact sites; interorganelle communication; lipid traffic calcium signaling; amphipathic helix; VPS13; VAP; ATG2 |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10070346 |
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