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Regulation of targeting determinants in interorganelle communication

Alli-Balogun, GO; Levine, TP; (2019) Regulation of targeting determinants in interorganelle communication. Current Opinion in Cell Biology , 57 pp. 106-114. 10.1016/j.ceb.2018.12.010. Green open access

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Abstract

The field of interorganelle communication is now established as a major aspect of intracellular organisation, with a profusion of material and signals exchanged between organelles. One way to address interorganelle communication is to study the interactions of the proteins involved, particularly targeting interactions, which are a key way to regulate activity. While most peripheral membrane proteins have single determinants for membrane targeting, proteins involved in interorganelle communication have more than one such determinant, sometimes as many as four, as in Vps13. Here we review the targeting determinants, showing how they can be relatively hard to find, how they are regulated, and how proteins integrate information from multiple targeting determinants.

Type: Article
Title: Regulation of targeting determinants in interorganelle communication
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ceb.2018.12.010
Publisher version: https://doi.org/10.1016/j.ceb.2018.12.010
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: membrane contact sites; interorganelle communication; lipid traffic calcium signaling; amphipathic helix; VPS13; VAP; ATG2
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10070346
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