UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Association of body mass index and waist-to-hip ratio with brain structure UK Biobank study

Hamer, M; Batty, GD; (2019) Association of body mass index and waist-to-hip ratio with brain structure UK Biobank study. Neurology , 92 (6) e594-e600. 10.1212/WNL.0000000000006879.

[img] Text
Batty_Association of body mass index and waist-to-hip ratio with brain structure. UK Biobank study_AAM.pdf - Accepted version
Access restricted to UCL open access staff

Download (598kB)

Abstract

OBJECTIVE: To examine the association of body mass index (BMI) and waist-to-hip ratio (WHR) with brain volume. METHODS: We used cross-sectional data from the UK Biobank study (n = 9,652, age 55.4 ± 7.5 years, 47.9% men). Measures included BMI, WHR, and total fat mass as ascertained from bioimpedance. Brain images were produced with structural MRI. RESULTS: After adjustment for a range of covariates, higher levels of all obesity measures were related to lower gray matter volume: BMI per 1 SD (β coefficient -4,113, 95% confidence interval [CI] -4,862 to -3,364), WHR (β coefficient -4,272, 95% CI -5,280 to -3,264), and fat mass (β coefficient -4,590, 95% CI -5,386 to -3,793). The combination of overall obesity (BMI ≥30 kg/m2) and central obesity (WHR >0.85 for women, >0.90 for men) was associated with the lowest gray matter compared with that in lean adults. In hypothesis-free testing with a Bonferroni correction, obesity was also related to various regional brain volumes, including caudate, putamen, pallidum, and nucleus accumbens. No associations between obesity and white matter were apparent. CONCLUSION: The combination of heightened BMI and WHR may be an important risk factor for gray matter atrophy.

Type: Article
Title: Association of body mass index and waist-to-hip ratio with brain structure UK Biobank study
Location: United States
DOI: 10.1212/WNL.0000000000006879
Publisher version: https://doi.org/10.1212/WNL.0000000000006879
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health
URI: https://discovery.ucl.ac.uk/id/eprint/10070308
Downloads since deposit
2Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item