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Synaptic vesicle protein 2A as a potential biomarker in synaptopathies

Heurling, K; Ashton, NJ; Leuzy, A; Zimmer, ER; Blennow, K; Zetterberg, H; Eriksson, J; ... Schöll, M; + view all (2019) Synaptic vesicle protein 2A as a potential biomarker in synaptopathies. Molecular and Cellular Neuroscience 10.1016/j.mcn.2019.02.001. (In press). Green open access

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Abstract

Measuring synaptic density in vivo using positron emission tomography (PET) imaging-based biomarkers targeting the synaptic vesicle protein 2A (SV2A) has received much attention recently due to its potential research and clinical applications in synaptopathies, including neurodegenerative and psychiatric diseases. Fluid-based biomarkers in proteinopathies have previously been suggested to provide information on pathology and disease status that is complementary to PET-based measures, and the same can be hypothesized with respect to SV2A. This review provides an overview of the current state of SV2A PET imaging as a biomarker of synaptic density, the potential role of fluid-based biomarkers for SV2A, and related future perspectives.

Type: Article
Title: Synaptic vesicle protein 2A as a potential biomarker in synaptopathies
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.mcn.2019.02.001
Publisher version: https://doi.org/10.1016/j.mcn.2019.02.001
Language: English
Additional information: This work is licensed under a CC BY-NC-ND license. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit (http://creativecommons.org/licenses/BY-NC-ND/4.0/)
Keywords: Biomarkers, Position emission tomography, SV2A, Synaptopathies
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10070133
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