Heurling, K;
Ashton, NJ;
Leuzy, A;
Zimmer, ER;
Blennow, K;
Zetterberg, H;
Eriksson, J;
... Schöll, M; + view all
(2019)
Synaptic vesicle protein 2A as a potential biomarker in synaptopathies.
Molecular and Cellular Neuroscience
10.1016/j.mcn.2019.02.001.
(In press).
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Abstract
Measuring synaptic density in vivo using positron emission tomography (PET) imaging-based biomarkers targeting the synaptic vesicle protein 2A (SV2A) has received much attention recently due to its potential research and clinical applications in synaptopathies, including neurodegenerative and psychiatric diseases. Fluid-based biomarkers in proteinopathies have previously been suggested to provide information on pathology and disease status that is complementary to PET-based measures, and the same can be hypothesized with respect to SV2A. This review provides an overview of the current state of SV2A PET imaging as a biomarker of synaptic density, the potential role of fluid-based biomarkers for SV2A, and related future perspectives.
| Type: | Article |
|---|---|
| Title: | Synaptic vesicle protein 2A as a potential biomarker in synaptopathies |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.mcn.2019.02.001 |
| Publisher version: | https://doi.org/10.1016/j.mcn.2019.02.001 |
| Language: | English |
| Additional information: | This work is licensed under a CC BY-NC-ND license. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit (http://creativecommons.org/licenses/BY-NC-ND/4.0/) |
| Keywords: | Biomarkers, Position emission tomography, SV2A, Synaptopathies |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10070133 |
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