Wagener, M;
Hoving, JC;
Ndlovu, H;
Marakalala, MJ;
(2018)
Dectin-1-Syk-CARD9 Signaling Pathway in TB immunity.
[Review].
Frontiers in Immunology
, 9
, Article 225. 10.3389/fimmu.2018.00225.
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Abstract
One of the first steps toward mounting an effective immune response to Mycobacterium tuberculosis (Mtb) is recognition of the pathogen through pattern-recognition receptors (PRRs) expressed by innate immune cells. Activation of the PRR Dectin-1 by an unknown mycobacterial ligand triggers an intracellular signaling cascade involving numerous proteins, including spleen tyrosine kinase, protein kinase C-delta, and caspase recruitment domain family member 9, some of which have been shown to influence host immune response to TB infection. Here, we review the role of Dectin-1 signaling pathway in anti-mycobacterial immunity and discuss its contribution in the control of Mtb infection, and potential applications in TB vaccine adjuvanticity.
| Type: | Article |
|---|---|
| Title: | Dectin-1-Syk-CARD9 Signaling Pathway in TB immunity |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fimmu.2018.00225 |
| Publisher version: | http://doi.org/10.3389/fimmu.2018.00225 |
| Language: | English |
| Additional information: | Copyright © 2018 Wagener, Hoving, Ndlovu and Marakalala. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | tuberculosis, Mycobacterium tuberculosis, dectin-1, C-type lectin receptors, innate immunity, TB immunity, pattern-recognition receptors, pathogen-associated molecular patterns |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10069993 |
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