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A multidimensional artefact-reduction approach to increase robustness of first-level fMRI analyses: Censoring vs. interpolating

Wilke, M; Baldeweg, T; (2019) A multidimensional artefact-reduction approach to increase robustness of first-level fMRI analyses: Censoring vs. interpolating. Journal of Neuroscience Methods , 318 pp. 56-68. 10.1016/j.jneumeth.2019.02.008. Green open access

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Abstract

BACKGROUND: This manuscript describes a new, multidimensional and data-driven approach to identify outlying datapoints from a first-level fMRI dataset. NEW METHOD: Using three different indicators of data corruption (the fast variance component of DVARS [Δ%D-var], scan-to-scan total displacement [STS], and each scan's overall explained variance [R2]), it identifies outlying datapoints while being balanced using Akaike'c corrected criterion (AIC C) to avoid overcorrection. We then explore the impact of censoring, interpolating, or both, to remove a bad scan's contribution to the final timeseries. RESULTS AND COMPARISON WITH EXISTING METHODS: Our results (using three real-life datasets and extensive simulations) show that motion-corrupted datapoints as well as non-motion related image artefacts are detected reliably. Using several indicators is shown to be an advantage over existing single-indicator solutions in different settings. As a result of using our algorithm, stronger activation (as detected by both T-value and number of activated voxels) and an increase in the temporal signal-to-noise ratio can be seen. The effects of censoring and interpolation are distinct and complex. CONCLUSIONS: The multidimensional approach described here is able to identify outlying datapoints in fMRI timeseries, with demonstrable positive effects on several outcome measures. While censoring datapoints may be preferable in many settings, the ultimate choice on which approach to choose may depend on the data at hand. Recommendations are provided for different scenarios.

Type: Article
Title: A multidimensional artefact-reduction approach to increase robustness of first-level fMRI analyses: Censoring vs. interpolating
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.jneumeth.2019.02.008
Publisher version: https://doi.org/10.1016/j.jneumeth.2019.02.008
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Functional MRI, outlier detection, artefact reduction, data censoring, data interpolation
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10069958
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