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Immune cells as targets for cardioprotection: New players and novel therapeutic opportunities

Andreadou, I; Cabrera-Fuentes, HA; Devaux, Y; Frangogiannis, NG; Frantz, S; Guzik, T; Liehn, E; ... Hausenloy, DJ; + view all (2019) Immune cells as targets for cardioprotection: New players and novel therapeutic opportunities. Cardiovascular Research 10.1093/cvr/cvz050. (In press).

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Abstract

New therapies are required to reduce myocardial infarct (MI) size and prevent the onset of heart failure in patients presenting with acute myocardial infarction (AMI), one of the leading causes of death and disability globally. In this regard, the immune cell response to AMI, which comprises an initial pro-inflammatory reaction followed by an anti-inflammatory phase, contributes to final MI size and post-AMI remodelling (left ventricular (LV) size and function). The transition between these two phases is critical in this regard, with a persistent and severe pro-inflammatory reaction leading to adverse LV remodelling and increased propensity for developing heart failure. In this review article, we provide an overview of the immune cells involved in orchestrating the complex and dynamic inflammatory response to AMI – these include neutrophils, monocytes/macrophages, and emerging new players such as dendritic cells, lymphocytes, pericardial lymphoid cells, and their interaction with cardiomyocytes, endothelial cells, and cardiac fibroblasts. We discuss potential reasons for past failures of anti-inflammatory cardioprotective therapies, and highlight emerging new treatment targets for modulating the immune cell response to AMI, as a potential therapeutic strategy to improve clinical outcomes in AMI patients. This article is part of a Cardiovascular Research Spotlight Issue entitled ‘Cardioprotection Beyond the Cardiomyocyte’, and emerged as part of the discussions of the European Union (EU)-CARDIOPROTECTION Cooperation in Science and Technology (COST) Action, CA16225.

Type: Article
Title: Immune cells as targets for cardioprotection: New players and novel therapeutic opportunities
Location: England
DOI: 10.1093/cvr/cvz050
Publisher version: https://doi.org/10.1093/cvr/cvz050
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Inflammation, acute myocardial infarction, dendritic cells, fibroblasts, lymphocytes, macrophages, monocytes, myocardial ischaemia/reperfusion injury
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science
URI: https://discovery.ucl.ac.uk/id/eprint/10069957
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