Pacman, Steven James;
(2019)
A modular approach to the synthesis of stretched luciferin analogues for use in near infrared optical imaging.
Doctoral thesis (Ph.D), UCL (University College London).
Preview |
Text
steve pacman PhD thesis v2.pdf - Accepted Version Download (3MB) | Preview |
Abstract
The introduction to this thesis covers the original work by McElroy, which established the requirements for light emission from firefly luciferin, and then the eventual elucidation of it chemical structure and synthesis. The mechanism of light emission is then discussed and a brief overview of some of the uses of bioluminescence in biology is discussed. The limitations of firefly luciferin are described along with some of the methods and attempts to address the limitations The results and discussion section describes the various attempts and progress towards a new alkyne bridged luciferin analogue. The various attempts to produce a new synthetic route to infraluciferin are described along with the successful route. The synthesis of a new analogue using the new synthetic route to infraluciferin is then presented. The future work and conclusions section give a summary of the work left that still warrants more attention and the successful results that were attained. The experimental section provides procedures and data for all the relevant compounds from the research carried out.
| Type: | Thesis (Doctoral) |
|---|---|
| Qualification: | Ph.D |
| Title: | A modular approach to the synthesis of stretched luciferin analogues for use in near infrared optical imaging |
| Event: | UCL (university college London) |
| Open access status: | An open access version is available from UCL Discovery |
| Language: | English |
| Additional information: | Copyright © The Author 2019. Original content in this thesis is licensed under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) Licence (https://creativecommons.org/licenses/by/4.0/). Any third-party copyright material present remains the property of its respective owner(s) and is licensed under its existing terms. Access may initially be restricted at the author’s request. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10069955 |
Archive Staff Only
 |
View Item |
