UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Assessing Errors Inherent in OCT-Derived Macular Thickness Maps

Odell, D; Dubis, AM; Lever, JF; Stepien, KE; Carroll, J; (2011) Assessing Errors Inherent in OCT-Derived Macular Thickness Maps. Journal of Ophthalmology , 2011 , Article 692574. 10.1155/2011/692574. Green open access

[thumbnail of ODell_OCTErrors.pdf]
Preview
Text
ODell_OCTErrors.pdf - Published Version

Download (3MB) | Preview

Abstract

SD-OCT has become an essential tool for evaluating macular pathology; however several aspects of data collection and analysis affect the accuracy of retinal thickness measurements. Here we evaluated sampling density, scan centering, and axial length compensation as factors affecting the accuracy of macular thickness maps. Forty-three patients with various retinal pathologies and 113 normal subjects were imaged using Cirrus HD-OCT. Reduced B-scan density was associated with increased interpolation error in ETDRS macular thickness plots. Correcting for individual differences in axial length revealed modest errors in retinal thickness maps, while more pronounced errors were observed when the ETDRS plot was not positioned at the center of the fovea (which can occur as a result of errant fixation). Cumulative error can exceed hundreds of microns, even under “ideal observer” conditions. This preventable error is particularly relevant when attempting to compare macular thickness maps to normative databases or measuring the area or volume of retinal features.

Type: Article
Title: Assessing Errors Inherent in OCT-Derived Macular Thickness Maps
Open access status: An open access version is available from UCL Discovery
DOI: 10.1155/2011/692574
Publisher version: https://doi.org/10.1155/2011/692574
Language: English
Additional information: © 2011 Daniel Odell et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10069868
Downloads since deposit
46Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item