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In Vitro Cell Models for Ophthalmic Drug Development Applications

Shafaie, S; Hutter, V; Cook, MT; Brown, MB; Chau, DYS; (2016) In Vitro Cell Models for Ophthalmic Drug Development Applications. BioResearch Open Access , 5 (1) pp. 94-108. 10.1089/biores.2016.0008. Green open access

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Abstract

Tissue engineering is a rapidly expanding field that aims to establish feasible techniques to fabricate biologically equivalent replacements for diseased and damaged tissues/organs. Emerging from this prospect is the development of in vitro representations of organs for drug toxicity assessment. Due to the ever-increasing interest in ocular drug delivery as a route for administration as well as the rise of new ophthalmic therapeutics, there is a demand for physiologically accurate in vitro models of the eye to assess drug delivery and safety of new ocular medicines. This review summarizes current existing ocular models and highlights the important factors and limitations that need to be considered during their use.

Type: Article
Title: In Vitro Cell Models for Ophthalmic Drug Development Applications
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1089/biores.2016.0008
Publisher version: https://doi.org/10.1089/biores.2016.0008
Language: English
Additional information: ª Sara Shafaie et al. 2016; Published by Mary Ann Liebert, Inc. This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
Keywords: cell culture, drug delivery, ophthalmology, tissue engineering, toxicity testing
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Biomaterials and Tissue Eng
URI: https://discovery.ucl.ac.uk/id/eprint/10069782
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