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Metabolically Active, Fully Hydrolysable Polymersomes

Zhu, Y; Poma, A; Rizzello, L; Gouveia, VM; Ruiz-Perez, L; Battaglia, G; Williams, CK; (2019) Metabolically Active, Fully Hydrolysable Polymersomes. Angewandte Chemie International Edition , 58 (14) pp. 4581-4586. 10.1002/anie.201814320. Green open access

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Abstract

The synthesis and aqueous self‐assembly of a new class of amphiphilic aliphatic polyesters are presented. These AB block polyesters comprise polycaprolactone (hydrophobe) and an alternating polyester from succinic acid and an ether‐substituted epoxide (hydrophile). They self‐assemble into biodegradable polymersomes capable of entering cells. Their degradation products are bioactive, giving rise to differentiated cellular responses inducing stromal cell proliferation and macrophage apoptosis. Both effects emerge only when the copolymers enter cells as polymersomes and their magnitudes are size dependent.

Type: Article
Title: Metabolically Active, Fully Hydrolysable Polymersomes
Location: Germany
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/anie.201814320
Publisher version: https://doi.org/10.1002/anie.201814320
Language: English
Additional information: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. https://creativecommons.org/licenses/by/4.0/
Keywords: cells, drug discovery, polymers, ring opening, self-assembly
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/10069758
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