Colao, IL;
Corteling, R;
Bracewell, D;
Wall, I;
(2018)
Manufacturing Exosomes: A Promising Therapeutic Platform.
Trends in Molecular Medicine
, 24
(3)
pp. 242-256.
10.1016/j.molmed.2018.01.006.
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Abstract
Extracellular vesicles, in particular the subclass exosomes, are rapidly emerging as a novel therapeutic platform. However, currently very few clinical validation studies and no clearly defined manufacturing process exist. As exosomes progress towards the clinic for treatment of a vast array of diseases, it is important to define the engineering basis for their manufacture early in the development cycle to ensure they can be produced cost-effectively at the appropriate scale. We hypothesize that transitioning to defined manufacturing platforms will increase consistency of the exosome product and improve their clinical advancement as a new therapeutic tool. We present manufacturing technologies and strategies that are being implemented and consider their application for the transition from bench-scale to clinical production of exosomes.
| Type: | Article |
|---|---|
| Title: | Manufacturing Exosomes: A Promising Therapeutic Platform |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.molmed.2018.01.006 |
| Publisher version: | http://doi.org/10.1016/j.molmed.2018.01.006 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | commercial manufacturing, exosomes, process development, regenerative medicine |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Biochemical Engineering |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10069527 |
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