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Binding deficits in visual short-term memory in patients with temporal lobe lobectomy.

Zokaei, N; Nour, MM; Sillence, A; Drew, D; Adcock, J; Stacey, R; Voets, N; ... Husain, M; + view all (2019) Binding deficits in visual short-term memory in patients with temporal lobe lobectomy. Hippocampus , 29 (2) pp. 63-67. 10.1002/hipo.22998. Green open access

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Abstract

Classical views of the medial temporal lobe (MTL) have established that it plays a crucial role in long-term memory (LTM). Here we demonstrate, in a sample of patients who have undergone anterior temporal lobectomy for the treatment of pharmacoresistant epilepsy, that the MTL additionally plays a specific, causal role in short-term memory (STM). Patients (n=22) and age-matched healthy control participants (n=26) performed a STM task with a sensitive continuous report measure. This paradigm allowed us to examine recall memory for object identity, location and object-location binding, independently on a trial-by-trial basis. Our findings point to a specific involvement of MTL in object-location binding, but, crucially, not retention of either object identity or location. Therefore the MTL appears to perform a specific computation: binding disparate features that belong to a memory. These results echo findings from previous studies, which have identified a role for the MTL in relational binding for LTM, and support the proposal that MTL regions perform such a function for both STM and LTM, independent of the retention duration. Furthermore, these findings and the methodology employed here may provide a simple, sensitive and clinically valuable means to test memory dysfunuction in MTL disorders.

Type: Article
Title: Binding deficits in visual short-term memory in patients with temporal lobe lobectomy.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/hipo.22998
Publisher version: https://doi.org/10.1002/hipo.22998
Language: English
Additional information: Copyright © 2018 The Authors. Hippocampus published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: Binding, Medial Temporal Lobe, Short term memory
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/10069406
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