Zokaei, N; Nour, MM; Sillence, A; Drew, D; Adcock, J; Stacey, R; Voets, N; ... Husain, M; + view all Zokaei, N; Nour, MM; Sillence, A; Drew, D; Adcock, J; Stacey, R; Voets, N; Sen, A; Husain, M; - view fewer (2019) Binding deficits in visual short-term memory in patients with temporal lobe lobectomy. Hippocampus , 29 (2) pp. 63-67. 10.1002/hipo.22998.

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Abstract

Classical views of the medial temporal lobe (MTL) have established that it plays a crucial role in long-term memory (LTM). Here we demonstrate, in a sample of patients who have undergone anterior temporal lobectomy for the treatment of pharmacoresistant epilepsy, that the MTL additionally plays a specific, causal role in short-term memory (STM). Patients (n=22) and age-matched healthy control participants (n=26) performed a STM task with a sensitive continuous report measure. This paradigm allowed us to examine recall memory for object identity, location and object-location binding, independently on a trial-by-trial basis. Our findings point to a specific involvement of MTL in object-location binding, but, crucially, not retention of either object identity or location. Therefore the MTL appears to perform a specific computation: binding disparate features that belong to a memory. These results echo findings from previous studies, which have identified a role for the MTL in relational binding for LTM, and support the proposal that MTL regions perform such a function for both STM and LTM, independent of the retention duration. Furthermore, these findings and the methodology employed here may provide a simple, sensitive and clinically valuable means to test memory dysfunuction in MTL disorders.

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